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n methylmorpholine  (Tokyo Chemical Industry)

 
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    Tokyo Chemical Industry n methylmorpholine
    N Methylmorpholine, supplied by Tokyo Chemical Industry, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/n+methylmorpholine/pmc13281378-110-11-16?v=Tokyo+Chemical+Industry
    Average 86 stars, based on 1 article reviews
    n methylmorpholine - by Bioz Stars, 2026-07
    86/100 stars

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    Image Search Results


    (A) Digital image of Fmoc-amino acid in the presence of 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC.HCl) and Oxyma prior to aqueous activation. (B) Fmoc-amino acid with EDC.HCl and Oxyma, N-methylmorpholine (NMM), in water mixed manually, showing incomplete dissolution and visible undissolved particulates. (C) The same mixture subjected to ultrasonic agitation at ambient temperature for 10 min, exhibiting persistent phase heterogeneity and incomplete solubilization. (D) Mixture heated to ∼50 °C with manual stirring, showing partial dispersion but continued presence of undissolved material. (E) Mixture heated to ∼50 °C and simultaneously subjected to ultrasonic irradiation for 10 min, resulting in a homogeneous yellow solution, indicating complete dissolution in water.

    Journal: bioRxiv

    Article Title: Thermal-Acoustic Activation of Hydrophobic Polystyrene Supports for High-Efficiency Aqueous Solid-Phase Peptide Synthesis

    doi: 10.64898/2026.05.05.722603

    Figure Lengend Snippet: (A) Digital image of Fmoc-amino acid in the presence of 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC.HCl) and Oxyma prior to aqueous activation. (B) Fmoc-amino acid with EDC.HCl and Oxyma, N-methylmorpholine (NMM), in water mixed manually, showing incomplete dissolution and visible undissolved particulates. (C) The same mixture subjected to ultrasonic agitation at ambient temperature for 10 min, exhibiting persistent phase heterogeneity and incomplete solubilization. (D) Mixture heated to ∼50 °C with manual stirring, showing partial dispersion but continued presence of undissolved material. (E) Mixture heated to ∼50 °C and simultaneously subjected to ultrasonic irradiation for 10 min, resulting in a homogeneous yellow solution, indicating complete dissolution in water.

    Article Snippet: N, N’ -diisopropylethylamine (DIPEA) (CAS Number: 387649), N-methylmorpholine (NMM) (CAS Number: 109-02-4), piperedine (PIP) (CAS Number: 110-89-4), (Acetic anhydride (CAS Number: 108-24-7) acetonitrile (ACN) (CAS Number: 75-05-8), methanol (MeOH) (CAS Number: 67-56-1), isopropyl alcohol (IPA) (CAS Number: 67-63-0), N, N’ -dimethylformamide (DMF) (CAS Number: 68-12-2), dichloromethane (DCM) (CAS Number: 75-09-2), trifluoroacetic acid (TFA) (CAS Number: 76-05-1), triisopropylsilane (TIS) (CAS Number: T1533), diethyl ether (CAS Number: 60-29-7), and tert-butyl methyl ether (CAS Number: 1634-04-4) were obtained from Loba Chemie Private Limited.

    Techniques: Activation Assay, Dissolution, Dispersion, Irradiation

    Schematic representation of the coupling mechanism of Fmoc-protected amino acids on 2-chlorotrityl chloride (2-CTC) polystyrene resin under thermal–acoustic conditions. Initially, N -Methylmorpholine (NMM) is dissolved in water ( Step-1 ), and the Fmoc-amino acid is further dissolved in this mixture under heating and ultrasonic irradiation, generating a homogeneous aqueous solution ( Step-2 ). Upon addition of EDC·HCl, the carboxylate group is activated to form an O -acylisourea intermediate ( Step-3 ), which is subsequently stabilized by Oxyma to produce a reactive active ester ( Step-4 ). Under thermal–acoustic conditions, the activated ester diffuses into the hydrophobic resin matrix and reacts with the free amine ( Step-5 ), resulting in amide bond formation and extension of the peptide chain ( Step-6 ).

    Journal: bioRxiv

    Article Title: Thermal-Acoustic Activation of Hydrophobic Polystyrene Supports for High-Efficiency Aqueous Solid-Phase Peptide Synthesis

    doi: 10.64898/2026.05.05.722603

    Figure Lengend Snippet: Schematic representation of the coupling mechanism of Fmoc-protected amino acids on 2-chlorotrityl chloride (2-CTC) polystyrene resin under thermal–acoustic conditions. Initially, N -Methylmorpholine (NMM) is dissolved in water ( Step-1 ), and the Fmoc-amino acid is further dissolved in this mixture under heating and ultrasonic irradiation, generating a homogeneous aqueous solution ( Step-2 ). Upon addition of EDC·HCl, the carboxylate group is activated to form an O -acylisourea intermediate ( Step-3 ), which is subsequently stabilized by Oxyma to produce a reactive active ester ( Step-4 ). Under thermal–acoustic conditions, the activated ester diffuses into the hydrophobic resin matrix and reacts with the free amine ( Step-5 ), resulting in amide bond formation and extension of the peptide chain ( Step-6 ).

    Article Snippet: N, N’ -diisopropylethylamine (DIPEA) (CAS Number: 387649), N-methylmorpholine (NMM) (CAS Number: 109-02-4), piperedine (PIP) (CAS Number: 110-89-4), (Acetic anhydride (CAS Number: 108-24-7) acetonitrile (ACN) (CAS Number: 75-05-8), methanol (MeOH) (CAS Number: 67-56-1), isopropyl alcohol (IPA) (CAS Number: 67-63-0), N, N’ -dimethylformamide (DMF) (CAS Number: 68-12-2), dichloromethane (DCM) (CAS Number: 75-09-2), trifluoroacetic acid (TFA) (CAS Number: 76-05-1), triisopropylsilane (TIS) (CAS Number: T1533), diethyl ether (CAS Number: 60-29-7), and tert-butyl methyl ether (CAS Number: 1634-04-4) were obtained from Loba Chemie Private Limited.

    Techniques: Irradiation